Radiotherapy and chemotherapy are the use of anticancer drugs or radiation as treatment methods, which have good short-term curative effect on various cancers.
However, while radiotherapy and chemotherapy kill cancer cells, they also do not selectively kill normal tissue cells, which are often referred to as toxic side effects or adverse reactions of radiotherapy and chemotherapy.
The efficacy of genistein in adjuvant chemoradiotherapy with enhanced efficacy and detoxification is very accurate.
The most common clinical adverse reactions of radiotherapy and chemotherapy are:
1. Myelosuppression:
The most notable feature of adverse reactions caused by radiotherapy and chemotherapy is that they often attack those tissues and organs that proliferate vigorously, especially the damage to the blood system is the most common clinical.
Mild adverse reactions can cause peripheral blood cells to decrease to varying degrees, but they can recover on their own after stopping treatment;
Serious adverse reactions can lead to myelosuppression, resulting in a significant decrease in peripheral blood cells, and severe infection secondary to a significant decrease in leukocytes, and a significant decrease in platelets, leading to fatal bleeding.
2. Gastrointestinal adverse reactions:
radiotherapy and chemotherapy can cause gastrointestinal mucosal damage, and gastrointestinal adverse reactions of different degrees occur.
In mild cases, stomach discomfort, nausea and vomiting, and not wanting to eat, etc.; .
3. Damage to organ function:
almost all chemotherapy drugs can cause damage to organs: liver damage: abdominal distension, nausea, loss of appetite, and even jaundice in mild cases, and liver failure in severe cases;
kidney damage: no obvious symptoms in the early stage Symptoms are often accompanied by clinical manifestations such as oliguria. Abnormal blood urea nitrogen and elevated serum creatinine are often signs of chronic or acute renal insufficiency;
Heart damage:
It can lead to the aggravation of the original heart disease, and can induce serious arrhythmia, which is manifested as tachycardia, premature beats, bradycardia, etc., which can lead to serious heart failure.
4. Decreased immune function:
The immune function of cancer patients is in a state of obvious disorder, losing the ability to monitor cancer cells, and mistakenly regard cancer cells as part of themselves, and allow cancer cells to continue to grow and proliferate in the body.
At the same time, radiotherapy and chemotherapy further destroy the patient's immune function, resulting in a further decline in immune function. And thus lead to serious infection, prompting the disease to aggravate or worsen.
5. In addition, radiotherapy and chemotherapy can also cause hair loss and skin damage.
To sum up, although the effects of radiotherapy and chemotherapy play a certain therapeutic role, at the same time, radiotherapy and chemotherapy can cause toxic reactions to important organs of the body without selective killing of normal tissue cells.
This brings great tissue damage and toxic side effects to patients, so that some patients do not die from cancer, but from overtreatment of cancer.
According to the existing experimental research literature, genistein can fight against the adverse reactions of radiotherapy and chemotherapy in the following aspects, and has the effect of adjuvant therapy.
1. It can resist the damage caused by radiotherapy and chemotherapy to peripheral blood cells, and also has obvious protective and promoting effects on bone marrow hematopoietic function. Effective prevention of radiotherapy and chemotherapy bone marrow damage, is conducive to the completion of radiotherapy and chemotherapy cycles and improve clinical efficacy.
2. Genistein is not only a strengthening agent for tonic treatment, but also a protective agent for the functions of various organs and tissues including the gastrointestinal tract.
It can effectively protect the gastric mucosa, improve gastrointestinal function, increase appetite and diet, Significantly reduce gastrointestinal adverse reactions caused by radiotherapy and chemotherapy.
3. Genistein can increase specific and non-specific immune function of cancer patients. Enhance the patient's physique, improve disease resistance, reduce the chance of infection, and increase the tolerance of the patient's tissues and organs to radiotherapy and chemotherapy.
4. By protecting the organ function, it can resist the damage of organ function caused by radiotherapy and chemotherapy.
A number of studies have found that genistein can promote the reversal of drug resistance in the drug-resistant cell line P388/ADM of leukemia and other cancers, thereby enhancing the cytotoxic effects of daunomycin and vinblastine.
Therefore, genistein can be used in the treatment of cancers that are resistant to various antitumor drugs.
The adjuvant treatment of genistein for radiotherapy and chemotherapy shows the advantages of high efficiency and non-toxicity.
In addition, genistein also has good performance in improving immunity, inhibiting the proliferation of cancer cells, inducing the transformation and apoptosis of cancer cells to normal cells, etc.
It is the embodiment of the idea of "human tumor coexistence" in cancer treatment.
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