What are the pharmacological properties of rutin extract?

 Oxygen molecules are reduced in the form of single electrons in cellular metabolism. 



O ions generated by oxygen molecules in the single-electron reduction will then generate H2O2 and extremely toxic OH free radicals in the body, thus affecting the smoothness of the skin and even accelerating the skin. 


The degree of aging, and the addition of rutin to the product can obviously remove the active oxygen free radicals produced by cells.


Rutin is a flavonoid compound, which is a strong oxidant for scavenging free radicals. 


It can terminate the chain reaction of free radicals, inhibit the peroxidation of polyunsaturated fatty acids on biofilms, remove lipid peroxidation products, and protect biofilms and sub- The integrity of cell structure plays an important role in the body.


Lipid peroxidation refers to a series of oxidation processes caused by reactive oxygen species attacking polyunsaturated fatty acids in biological membranes.


Through the determination and analysis of SOD activity, free radical lipid peroxidation product MDA content and large liver lipofuscin (Lipofuscin) content in rats, Zhu Jianlin et al found that rutin has an inhibitory effect on lipid peroxidation in castrated rats, and can inhibit the removal of lipid peroxidation in castrated rats. 

Decreased antioxidant capacity of the antioxidant system in rats after exposure.


Rutin has anti-oxidative effect against the decline of antioxidant capacity caused by the decline of endogenous estrogen.


High-density lipoprotein (HDL) has anti-atherosclerotic effects. 

However, HDL, like low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), can also be oxidatively modified in vitro.


Once HDL is oxidatively modified to Ox-HDL, it has atherogenic effect.


Meng Fang et al. used Cu2+-mediated oxidative modification in vitro to explore the effect of rutin on the oxidative modification of HDL. 


The conclusion shows that rutin can significantly inhibit the oxidative modification of HDL.


 The pathogenesis of many cardiovascular and cerebrovascular diseases, such as thrombosis, atherosclerosis, inflammatory response and ischemia-reperfusion free radical injury, are closely related to platelet activating factor.


(platelet activating factor, PAF) is closely related, so antagonizing the effect of PAF is an important way to alleviate ischemic cardiovascular and cerebrovascular diseases.


Experiments show that rutin can concentration-dependently antagonize the specific binding of PAF to rabbit platelet membrane receptors, inhibit PAF-mediated rabbit platelet adhesion and increase the concentration of free Ca2+ in PMNs, indicating that the mechanism of rutin's anti-PAF action is by inhibiting PAF Receptor activation, thereby blocking the response induced by PAF, thereby protecting the cardiovascular system, the results show that rutin is a PAF receptor antagonist.

Rutin can effectively prevent the occurrence of hypocalcemia and reduce the concentration of Ca2+ in pancreatic tissue.


The study found that rutin can increase the content of phospholipase A2 (PLA2) in pancreatic tissue of rats, suggesting that rutin may have an inhibitory effect on the release and activation of PLA2 in pancreatic tissue;


Rutin can effectively prevent the occurrence of hypocalcemia in AP rats, possibly by preventing the influx of Ca2+ and reducing the Ca2+ overload of pancreatic tissue cells, thereby reducing the pathological damage to AP.

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