The efficacy and role of luteolin?

The efficacy and role of luteolin?

Luteolin belongs to flavones (flavones) phytochemicals, mainly found in honeysuckle, chrysanthemum, Nepeta, Prunella vulgaris and other medicines, as well as thyme, Brussels sprouts, cabbage, cauliflower, beets, broccoli and carrots, etc. 

Vegetables, and distributed in the form of glycosides in a variety of plants, such as celery, green pepper, perilla leaves, etc. 

The pure luteolin is a yellow crystalline powder, slightly soluble in water, soluble in alkali Sanyi Chinese solution, and stable under normal conditions.

The main effects of luteolin are anti-inflammatory, antibacterial, anti-tumor, anti-high uric acid and so on.

Luteolin is a component extracted from plants such as Prunella vulgaris or blue orchid. It is called flavonoids and has a variety of pharmacological activities, which can inhibit and activate cells and reduce toxic substances. in release,

Therefore, it can protect nerves, anti-inflammatory, anti-uric acid and other effects, and can relieve the phenomenon of gout. The substance can effectively help maintain the normal level of uric acid in the body, and play a role in improving the prevention of hyperuric acid. Long-term use can help improve the symptoms of gout. It is very suitable for people with hyperuric acid gout to drink daily.

Luteolin is a natural flavonoid found in a variety of plants, including broccoli, pepper, thyme, and celery. 

Because it inhibits the activation of mast cells and microglia and reduces the release of substances such as histamine, serotonin, glutamate, and pro-inflammatory factors, luteolin has multiple effects such as antioxidant, Protect and enhance the attention and social skills of children with autism.

Although flavonoids are generally considered safe, there are some side effects, such as allergic reactions in individuals with G6PD deficiency who take flavonoids extracted from peanut shells and fava beans. Therefore, flavonoids are best not taken with other natural polyphenols or with drugs that affect liver metabolism.

Physiological function of luteolin

 anti-oxidation

   The flavonoids represented by luteolin and so on have the function of free radical scavenger, which mainly generates stable semi-quinone free radicals through the reaction of phenolic hydroxyl groups with free radicals, thereby terminating the free radical chain reaction. 

Chemical analysis studies have shown that luteolin has the strongest resistance to quercetin and capsaicin under equimolar concentrations.

Oxidative activity [3]. The results of TBA rapid assay showed that luteolin showed good antioxidant activity in sesame oil,

The effective concentration is 0.02%. At this concentration, the antioxidant effect of luteolin in sesame oil and lard is similar to that of BHT, and the antioxidant capacity in lard is stronger than that of tea polyphenols [4].

Bacteriostatic

  A certain concentration of luteolin can inhibit the growth of Staphylococcus, Bacillus subtilis, Saccharomyces cerevisiae and Escherichia coli, and also inhibit the growth of catarrhal bacteria, Candida albicans, Proteus, and can be used as food preservatives, such as Yanchang moon cakes, peach cakes, etc. Shelf life, inhibit the deterioration of oily foods, etc. [5].

Anti-inflammatory

   Luteolin has anti-inflammatory effect, and the occurrence of inflammation is closely related to T cells, B cells, NK cells, macrophages, etc. in vivo. Luteolin and other flavonoids are anti-inflammatory mainly by affecting the process of cell secretion and the interaction between mitotic cells. and reduce the production of killer T cells.

Antitumor

   Luteolin induces tumor cell apoptosis mainly through targeted regulation of signal transduction, gene expression, enzyme activation or inhibition in cell growth, and has a broad anti-cancer spectrum.

The anti-tumor mechanism of luteolin can directly act on tumor cells to interfere with cell metabolism, inhibit cell growth, and induce or sensitize cell apoptosis;

It can also play an anti-tumor effect by enhancing the immune function of the body. It is a very promising potential anti-tumor drug, which can reduce the incidence of colon cancer and ovarian cancer.

other physiological functions

   The relevant pharmacological and clinical test results show that luteolin has the pharmacological effects of lowering blood lipids and cholesterol, lowering blood pressure and regulating immunity in both directions.

Du Shuhu et al. conducted a preliminary study on the in vitro procoagulant effect of luteolin, the main chemical component of Peach Grass, and the results showed that luteolin had a better procoagulant effect.

In addition, luteolin can inhibit the production of immunoglobulin mast cells, has the effect of treating asthma, can relieve bronchitis, and can be used to treat dry skin itching.